Naratriptan Chanelle Use In Pregnancy & Lactation

Fertility, Pregnancy and lactation: The safe use of naratriptan in pregnant women has not been established. Evaluation of experimental animal studies does not indicate any direct teratogenic effects or harmful effects on peri- and postnatal development. However, delays in foetal ossification and possible effects on embryo viability have been observed in the rabbit.
Because animal reproduction studies are not always predictive of human response administration of naratriptan should only be considered if the expected benefit to the mother is greater than any possible risk to the foetus.
Naratriptan and/or drug related metabolites are secreted into the milk of lactating rats.
Transient effects in the pre and post-natal development of neonatal rats were observed only at maternal exposures sufficiently in excess of maximum human exposure. No studies have been conducted to determine the level of transference of naratriptan into breast milk of nursing women. It is recommended that infant exposure be minimised by avoiding breast-feeding for 24 hours after treatment.